Tetrahedron

Cyclization reactions of N-(2-chloroethylcarbamoyl) amino acids

HS Vargha, H Medzihradszky-Schweiger, F Ruff…

Index: Vargha, H. S.; Medzihradszky-Schweiger, H.; Ruff, F.; Medzihradszky, K. Tetrahedron, 1983 , vol. 39, # 13 p. 2255 - 2258

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Citation Number: 4

Abstract

Intramolecular cyclization of the N-(2-chloroethylcarbamoyl) derivatives of glycine, valine and phenylalanine give imidazolidone, oxazoline and hydantoin derivatives. The imidazolidone and oxazoline derivatives possess alkylating activity toward NBP. but the hydantoins do not. N-(2-Chloroethylcarbamoyl) glycine reacts with the mercapto group of cysteine; thus, this alkylating group may be useful for receptor labelling.