Tetrahedron

Synthesis of chiral amino acids with metal ion chelating side chains from l-serine using Negishi cross-coupling reaction

M Kruppa, G Imperato, B König

Index: Kruppa, Michael; Imperato, Giovanni; Koenig, Burkhard Tetrahedron, 2006 , vol. 62, # 7 p. 1360 - 1364

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Citation Number: 8

Abstract

The scope of the Negishi cross-coupling reaction of organozinc compounds derived from chiral amino acids was extended to electron rich iodoanilines and iodobenzylamines as coupling reagents. The protocol allows the direct modification of serine into phenylalanine derivatives bearing metal ion chelating ligands in their side chain, such as amino esters and. The preparation of metal complex labeled peptides, the construction of synthetic receptors ...