Resolution of β-aminoalcohols and 1, 2-diamines using fractional crystallization of diastereomeric salts of dehydroabietic acid

Z Guangyou, L Yuquing, W Zhaohui, H Nohira…

Index: Guangyou, Zhang; Yuquing, Liao; Zhaohui, Wang; Nohira, Hiroyuki; Hirose, Takuji Tetrahedron Asymmetry, 2003 , vol. 14, # 21 p. 3297 - 3300

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Citation Number: 46

Abstract

(S)-(+)-1-Amino-3-phenyloxy-2-propanol,(R)-(−)-2-amino-1-phenylethanol,(S)-(+)-1-amino-2- propanol,(1S, 2S)-(+)-2-aminocyclohexanol and (1S, 2S)-(+)-1, 2-diaminocyclohexane were resolved using dehydroabietic acid. It was shown that good to high enantiomeric purity, between 81∼> 99% ee, was obtained and that dehydroabietic acid could be easily and efficiently recovered in a reusable form.