Tetrahedron

The conversion of 2-cyano cyanothioformanilides into 3-aminoindole-2-carbonitriles using triphenylphosphine

PA Koutentis, SS Michaelidou

Index: Koutentis, Panayiotis A.; Michaelidou, Sophia S. Tetrahedron, 2010 , vol. 66, # 32 p. 6032 - 6039

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Citation Number: 7

Abstract

2-Cyano cyanothioformanilide 3a reacts with triphenylphosphine in the presence of water to give 2-(cyanomethyleneamino) benzonitrile 4a, 2-(cyanomethylamino) benzonitrile 5, 3- aminoindole-2-carbonitrile 2a and (2-cyanoindol-3-yl) iminotriphenylphosphorane 6a. In the presence of p-toluenesulfonic acid in MeOH the reaction between 2-cyano cyanothioformanilide 3a and triphenylphosphine (2equiv) gives 3-aminoindole-2- ...