Synthesis and structure/antioxidant activity relationship of novel catecholic antioxidant structural analogues to hydroxytyrosol and its lipophilic esters
R Bernini, F Crisante, M Barontini…
Index: Bernini, Roberta; Mincione, Enrico; Barontini, Maurizio; Crisante, Fernanda Journal of Agricultural and Food Chemistry, 2008 , vol. 56, # 19 p. 8897 - 8904
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Citation Number: 31
Abstract
A large panel of novel catecholic antioxidants and their fatty acid or methyl carbonate esters has been synthesized in satisfactory to good yields through a 2-iodoxybenzoic acid (IBX)- mediated aromatic hydroxylation as the key step. The new catechols are structural analogues of naturally occurring hydroxytyrosol (3, 4-DHE). To evaluate structure/activity relationships, the antioxidant properties of all catecholic compounds were evaluated in ...
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