Synthesis of some new 3 (2H)-pyridazinone derivatives and evaluation of their analgesic-anti-inflammatory and antimicrobial activities
M Sukuroglu, C Yamali, D Tiryaki…
Index: Sukuroglu, Murat; Yamali, Cem; Tiryaki, Didem; Onurdag, Fatma Kaynak; Akkol, Esra; Dogruer, Deniz Songuel Letters in Drug Design and Discovery, 2013 , vol. 10, # 6 p. 507 - 514
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Abstract
In this study, 15 new 3 (2H)-pyridazinone derivatives carrying N-(4- substitutedphenylmethylidene) acetohydrazide moiety on lactam nitrogen were synthesized and their chemical structures were confirmed by 1H-NMR, mass, and elemental analysis. Analgesic and anti-inflammatory activities of the synthesized compounds were evaluated in mice. Among the synthesized compounds, compound 11e exhibited the best analgesic ...
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