Discovery of new anti-depressants from structurally novel 5-HT 3 receptor antagonists: Design, synthesis and pharmacological evaluation of 3-ethoxyquinoxalin-2- …

R Mahesh, T Devadoss, DK Pandey, S Bhatt

Index: Mahesh, Radhakrishnan; Devadoss, Thangaraj; Pandey, Dilip Kumar; Bhatt, Shvetank Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 4 p. 1253 - 1256

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Citation Number: 13

Abstract

A novel series of 3-ethoxyquinoxalin-2-carboxamides were designed as per the pharmacophoric requirements of 5-HT3 receptor antagonist using ligand-based approach. The desired carboxamides were synthesized from the key intermediate, 3-ethoxyquinoxalin- 2-carboxylic acid by coupling with appropriate amines in the presence of 1-(3- dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC· HCl) and 1- ...