Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics

K Long, TA Edwards, AJ Wilson

Index: Long, Kerya; Edwards, Thomas A.; Wilson, Andrew J. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4034 - 4040

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Citation Number: 23

Abstract

Protein–protein interactions (PPIs) mediate cellular pathways and are implicated in numerous aberrant conditions. α-Helix mimetics—small molecules that reproduce the spatial projection of key residues from an α-helix involved in a PPI—are attractive generic templates for development of screening libraries, however library syntheses of α-helix mimetics with diverse functionality are less established. This manuscript describes the automated, ...