Novel applications of vinylogous Mannich reactions. Total synthesis of rugulovasines A and B

SF Martin, S Liras

Index: Martin; Liras Journal of the American Chemical Society, 1993 , vol. 115, # 22 p. 10450 - 10451

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Citation Number: 39

Abstract

The rugulovasines A and B (lqb), which were first isolated from Penicillium concavorugulosiuml and then from Penicillium islandicum, 2 represent novel structural types within the family of the Ergot alkaloid^.^ Interestingly, the rugulovasines A and B were isolated in racemic form, and they were also observed to interconvert upon warming. To account for these facts, the mechanism depicted in Scheme I was proposed, in which la ...