Design, synthesis and in vitro antitumor evaluation of novel diaryl urea derivatives bearing sulfonamide moiety

…, K Tang, Y Li, DL Yin, XG Chen, HH Huang

Index: Luo, Can; Tang, Ke; Li, Yan; Yin, Dali; Chen, Xiaoguang; Huang, Haihong Science China Chemistry, 2013 , vol. 56, # 11 p. 1564 - 1572

Full Text: HTML

Citation Number: 5

Abstract

Abstract A novel series of diaryl urea derivatives bearing sulfonamide moiety have been designed and synthesized. Their in vitro antitumor effect against human cancer cell lines MX- 1, A375, HepG2, Ketr3 and HT-29 was screened and evaluated by the standard MTT assay with sorafenib as the positive control. Some of the compounds showed significant inhibitory activity against multiple cell lines compared to sorafenib. In particular, 2, 6-dimethyl-4-{6-[3 ...