Development and optimization of piperidyl-1, 2, 3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis

…, K Tsuboi, LR Whitby, AE Speers, H Pugh…

Index: Hsu, Ku-Lung; Tsuboi, Katsunori; Whitby, Landon R.; Speers, Anna E.; Pugh, Holly; Inloes, Jordon; Cravatt, Benjamin F. Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8257 - 8269

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Citation Number: 11

Abstract

We have previously shown that 1, 2, 3-triazole ureas (1, 2, 3-TUs) act as versatile class of irreversible serine hydrolase inhibitors that can be tuned to create selective probes for diverse members of this large enzyme class, including diacylglycerol lipase-β (DAGLβ), a ...