Sodium channel binding and anticonvulsant activities of hydantoins containing conformationally constrained 5??phenyl substituents

WJ Brouillette, GB Brown, TM Delorey…

Index: Brouillette; Brown; DeLorey; Liang Journal of Pharmaceutical Sciences, 1990 , vol. 79, # 10 p. 871 - 874

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Citation Number: 59

Abstract

Abstract As a preliminary investigation of the importance of the aromatic ring orientation in interactions of 5-phenylhydantoins with the anticonvulsant site on the neuronal voltage- sensitive sodium channel, two isomeric hydantoins containing conformationally constrained phenyl rings and their monocyclic analogues were synthesized. One, a spiro-hydantoin (2) derived from α-tetralone, contains the plane of the phenyl ring in an orientation ...