Journal of Heterocyclic Chemistry

The hydroxyacetylpiperidines and their N??benzyl derivatives. The 2??hydroxymethyl??2??piperidyl??and 2??hydroxymethyl??2??pyridyl??1, 3??dioxolanes

AT Nielsen, EN Platt

Index: Nielsen,A.T.; Platt,E.N. Journal of Heterocyclic Chemistry, 1969 , vol. 6, p. 891 - 900

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Citation Number: 2

Abstract

Abstract The hydroxyacetylpiperidines, their ethylene ketals, and the N-benzyl derivatives of these new piperidines have been synthesized. Methylolation of 2-(2-and 4-pyridyl)-1, 3- dioxolanes by heating with paraformaldehyde at 185 led to 2-hydroxymethyl-2-(2-and 4- pyridyl)-i, 3-dioxolanes (7, 8, respectively). 2-Hydroxymethyl-2-(3-pyridyl)-1, 3-dioxolane (13) was obtained by reaction of 2-bromomethyl-2-(3-pyridyl)-1, 3-dioxolane with aqueous ...