Click Mechanochemistry: Quantitative Synthesis of “Ready to Use” Chiral Organocatalysts by Efficient Two??Fold Thiourea Coupling to Vicinal Diamines

…, MD Igrc, M Eckert??Maksić, T Friščić

Index: Strukil, Vjekoslav; Igrc, Marina D.; Eckert-Maksic, Mirjana; Friscic, Tomislav Chemistry - A European Journal, 2012 , vol. 18, # 27 p. 8464 - 8473

Full Text: HTML

Citation Number: 38

Abstract

Abstract Mechanochemical methods of neat grinding and liquid-assisted grinding have been applied to the synthesis of mono-and bis (thiourea) s by using the click coupling of aromatic and aliphatic diamines with aromatic isothiocyanates. The ability to modify the reaction conditions allowed the optimization of each reaction, leading to the quantitative formation of chiral bis (thiourea) s with known uses as organocatalysts or anion sensors. Quantitative ...