Synthesis of polyhydroxysterols (V): efficient and stereospecific synthesis of 24-methylene-cholest-5-ene-3β, 7α-diol and its C-7 epimer
W Lu, C Zhang, L Zeng, J Su
Index: Lu, Weigang; Zhang, Cuixian; Zeng, Longmei; Su, Jingyu Steroids, 2004 , vol. 69, # 13-14 p. 803 - 808
Full Text: HTML
Citation Number: 19
Abstract
This paper describes the efficient and stereospecific synthesis of cytotoxic dihydroxylated sterols, 24-methylene-cholest-5-ene-3β, 7α-diol 1, and its C-7 epimer, 24-methylene-cholest- 5-ene-3β, 7β-diol 2. The crux of the synthesis is that the selective allylic oxidation of 24- methylene-cholesteryl acetate proceeds to 24-methylene-7-keto-cholesteryl acetate without extensive byproduct formation from reaction at the Δ24 (28) double bond. This ...
Related Articles:
[Back, Thomas G.; Proudfoot, John R.; Djerassi, Carl Tetrahedron Letters, 1986 , vol. 27, # 20 p. 2187 - 2190]
[Cui, Jian Guo; Lin, Cui Wu; Zeng, Long Mei; Su, Jing Yu Steroids, 2002 , vol. 67, # 13-14 p. 1015 - 1019]
[Cui, Jian Guo; Lin, Cui Wu; Zeng, Long Mei; Su, Jing Yu Steroids, 2002 , vol. 67, # 13-14 p. 1015 - 1019]
[Cui, Jian Guo; Lin, Cui Wu; Zeng, Long Mei; Su, Jing Yu Steroids, 2002 , vol. 67, # 13-14 p. 1015 - 1019]
[Cui, Jian Guo; Lin, Cui Wu; Zeng, Long Mei; Su, Jing Yu Steroids, 2002 , vol. 67, # 13-14 p. 1015 - 1019]