Journal of medicinal chemistry

Synthesis and biological activity of potential antimetabolites

GI Glover, SO Nelson, GR Kaeder

Index: Glover,G.I. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 452 - 453

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Citation Number: 1

Abstract

Several known a-amino acid analogues and a new compound, N- chloroacetylphosphoramidate, a carbamyl phosphate analogue, were screened as antitumor agents. All gave 50% growth inhibition of cultures of human epidemeroid carcinoma of the nasopharynx at dosage levels of 2-8 fig/ml while showing no activity against L1210 lymphoid leukemia in vivo in BDFi mice.