Advanced Synthesis & Catalysis

Copper??Catalyzed Asymmetric Allylic Alkylation of Racemic Cyclic Substrates: Application of Dynamic Kinetic Asymmetric Transformation (DYKAT)

JB Langlois, A Alexakis

Index: Langlois, Jean-Baptiste; Alexakis, Alexandre Advanced Synthesis and Catalysis, 2010 , vol. 352, # 2-3 p. 447 - 457

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Citation Number: 27

Abstract

Abstract The copper-catalyzed asymmetric allylic alkylation (AAA) is of great interest in organic synthesis. This reaction was extensively studied using a broad range of substrates, ligands and organometallic reagents. However, the use of racemic substrates was still limited. Although some processes of kinetic resolution are reported in the literature, no examples of quantitative deracemization are described as is the case for the Pd-catalyzed ...