Synthesis, Molecular Docking, and Biofilm Formation Inhibitory Activity of 5??Substituted 3, 4??Dihalo??5H??furan??2??one Derivatives on Pseudomonas aeruginosa

…, WN Chen, C Cheng, QL Zhang, MB Dai…

Index: Liu, Guo-Yong; Guo, Bao-Qin; Chen, Wan-Na; Cheng, Chao; Zhang, Qian-Lan; Dai, Mi-Bei; Sun, Jun-Rong; Sun, Ping-Hua; Chen, Wei-Min Chemical Biology and Drug Design, 2012 , vol. 79, # 5 p. 628 - 638

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Citation Number: 12

Abstract

Pseudomonas aeruginosa (P. aeruginosa) colonize on most wounds and live as biofilm, which causes antibiotic resistance and wounds unhealed. To investigate the effects of 5- substituted 3, 4-dihalo-5H-furan-2-one compounds on biofilm formation of P. aeruginosa, a set of 5-(aryl-1¢-hydroxy-methyl)-or 5-(aryl-2-methylene)-3, 4-dihalo-5H-furan-2-one compounds were designed and synthesized. Their inhibitory activities on biofilm formation ...