Synthesis of isocoumarin derivatives via the copper-catalyzed tandem sequential cyclization of 2-halo-N-phenyl benzamides and acyclic 1, 3-diketones
…, CC Wang, DK Barange, CW Kuo, PM Lei…
Index: Kavala, Veerababurao; Wang, Cheng-Chuan; Barange, Deepak Kumar; Kuo, Chun-Wei; Lei, Po-Min; Yao, Ching-Fa Journal of Organic Chemistry, 2012 , vol. 77, # 11 p. 5022 - 5029
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Citation Number: 51
Abstract
A facile and rapid synthesis of isocoumarin derivatives using a copper-catalyzed tandem C– C/C–O coupling strategy from readily available substrates is described. The reactions of a wide range of 2-iodo-N-phenyl benzamides and acyclic diketones as starting materials were investigated.
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