3-Substituted Isocoumarins as Thymidine Phosphorylase Inhibitors

…, S Hussain, S Perveen, MI Choudhary

Index: Khan, Khalid Mohammed; Ahmed, Sumbul; Hussain, Sajjad; Ambreen, Nida; Perveen, Shahnaz; Choudhary, M. Iqbal Letters in Drug Design and Discovery, 2010 , vol. 7, # 4 p. 265 - 268

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Citation Number: 4

Abstract

3-Substituted isocoumarins 1-19 were synthesized and evaluated for their thymidine phosphorylase inhibitory activity. Eight (8) compounds exhibited a varying degree of inhibitory activity towards thymidine phosphorylase from E. coli with IC50 values between 61- 402 iM. The activities were compared with the standard 7-deazaxanthine (IC50= 39.28±0.76 iM).