NMR and molecular modeling study of active and inactive taxol analogues in aqueous and nonaqueous solution

HJ Williams, AI Scott, RA Dieden…

Index: Moyna, Guillermo; Williams, Howard J.; Scott Synthetic Communications, 1996 , vol. 26, # 11 p. 2235 - 2239

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Citation Number: 57

Abstract

The conformations of the biologically active taxol analogs Taxotere®, 3R, 4R, and 4S, and the biologically inactive analog 3S were evaluated in CDCl3 and DMSO-water solution using 1H NMR coupling constant and NOESY data and molecular modeling. The solution

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