The synthesis of compounds with potential anti-folic acid activity. Part I. 7-Amino-and 7-hydroxy-pteridines

RGW Spickett, GM Timmis

Index: Spickett; Timmis Journal of the Chemical Society, 1954 , p. 2887,2891

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Citation Number: 28

Abstract

The unequivocal synthesis is reported of a number of 7-amino-and 7-hydroxy-pteridines by the reaction of 4-amino-5-nitrosopyrimidines with phenylacetonitriles and phenylacetyl chlorides respectively. Sodium alkoxides were effective catalysts for the reaction with the