Synthesis and pharmacological evaluation of 2, 4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors

CN Kapanda, J Masquelier, G Labar…

Index: Kapanda, Coco N.; Masquelier, Julien; Labar, Geoffray; Muccioli, Giulio G.; Poupaert, Jacques H.; Lambert, Didier M. Journal of Medicinal Chemistry, 2012 , vol. 55, # 12 p. 5774 - 5783

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Citation Number: 17

Abstract

Monoacylglycerol lipase (MAGL) is responsible for signal termination of 2- arachidonoylglycerol (2-AG), an endocannabinoid neurotransmitter endowed with several physiological effects. Previously, we showed that the arylthioamide scaffold represents a privileged template for designing MAGL inhibitors. A series of 37 compounds resulting from pharmacomodulations around the arylthioamide template were synthesized and tested to ...