The effect of phenyl substituents on the release rates of esterase-sensitive coumarin-based prodrugs.
Y Liao, S Hendrata, SY Bae, B WANG
Index: Liao; Hendrata; Sung Yong Bae; Wang Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 8 p. 1138 - 1147
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Citation Number: 14
Abstract
A coumarin-based prodrug system has been recently developed in our laboratory for the preparation of esterase-sensitive prodrugs of amines, peptides, and peptidomimetics. The drug release rates from this prodrug system were found to be dependent on the structural features of the drug moiety. In certain cases, the release can be undesirably slow for drugs that are secondary amines with relatively high pK a's. Aimed at finding ways to manipulate ...
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