Design, synthesis and pharmacological evaluation of conformationally restricted N-arylsulfonyl-3-aminoalkoxy indoles as a potential 5-HT6 receptor ligands

RVS Nirogia, R Kambhampati…

Index: Journal of Enzyme Inhibition and Medicinal Chemistry, , vol. 26, # 3 p. 341 - 349

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Citation Number: 7

Abstract

... Journal of Enzyme Inhibition and Medicinal ... on ring A and α-methyl group in the side chain was least active with 46.68% inhibition at 5-HT 6 R. Its analogue 8g, with β-methyl group in the side chain was found to have better binding affinity (74.13% inhibition), indicating that ...