Eco??Friendly Combination of the Immobilized PGA Enzyme and the S??Phacm Protecting Group for the Synthesis of Cys??Containing Peptides
…, T Bruckdorfer, M Royo, J Tulla??Puche…
Index: Gongora-Benitez, Miriam; Basso, Alessandra; Bruckdorfer, Thomas; Royo, Miriam; Tulla-Puche, Judit; Albericio, Fernando Chemistry - A European Journal, 2012 , vol. 18, # 50 p. 16166 - 16176
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Citation Number: 8
Abstract
Abstract Enzyme-labile protecting groups have emerged as a green alternative to conventional protecting groups. These groups introduce a further orthogonal dimension and eco-friendliness into protection schemes for the synthesis of complex polyfunctional organic molecules. S-Phacm, a Cys-protecting group, can be easily removed by the action of a covalently immobilized PGA enzyme under very mild conditions. Herein, the versatility and ...
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