Tetrahedron Letters

Nouvelle voie d'acces au diethylacetal de l'amino-2 cyano-3 formyl-5 pyrazine

JP Mayer, JP Fleury

Index: Mayer, Jean-Philippe; Fleury, Jean-Pierre Tetrahedron Letters, 1980 , vol. 21, p. 3759 - 3762

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Abstract

Abstract An unequivocal two step synthesis of 2-amino-3-cyano-5-formylpyrazine diethylacetal, starting from dimethylaminoacrolein and O-tosylisonitrosomalononitrile, is described. This pyrazine is a key intermediate for the preparation of folic acid and various analogues.