Antitrichomonal activity of mesoionic thiazolo [3, 2-a] pyridines

…, EB Sjogren, TR Matthews

Index: Walker, Keith A. M.; Sjogren, Eric B.; Matthews, Thomas R. Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1673 - 1679

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Citation Number: 6

Abstract

Scheme I related compounds4 have shown that the remarkable specificity toward anaerobes (and facultative anaerobes) is due to the higher reduction potentials occurring in these cells relative to aerobic (eg, mammalian) cells. In susceptible cells, reduction of metronidazole establishes a concentration gradient6p7 favoring further diffusion into these cells, with the accumulation of reduction products. It has been shown that, during the ...