Chemo-enzymatic enantio-convergent asymmetric synthesis of (R)-(+)-Marmin
K Edegger, SF Mayer, A Steinreiber, K Faber
Index: Edegger, Klaus; Mayer, Sandra F.; Steinreiber, Andreas; Faber, Kurt Tetrahedron, 2004 , vol. 60, # 3 p. 583 - 588
Full Text: HTML
Citation Number: 8
Abstract
Asymmetric biohydrolysis of trisubstituted terpenoid oxiranes (–) was accomplished by employing the epoxide hydrolase activity Rhodococcus and Streptomyces spp. Depending on the biocatalyst, the biohydrolysis proceeded in an enantio-convergent fashion and gave the corresponding vic-diols in up to 97% ee at conversions beyond the 50%-threshold. In order to avoid a depletion of the ee of product by further oxidative metabolism, ...
Related Articles:
7-Hydroxycoumarin derivatives from the juice oil of Citrus hassaku
[Masuda, Toshiya; Muroya, Yukari; Nakatani, Nobuji Phytochemistry (Elsevier), 1992 , vol. 31, # 4 p. 1363 - 1366]
[Aziz, Mostafa; Rouessac, Francis Tetrahedron, 1988 , vol. 44, # 1 p. 101 - 110]
[Aziz, Mostafa; Rouessac, Francis Tetrahedron, 1988 , vol. 44, # 1 p. 101 - 110]
[Aziz, Mostafa; Rouessac, Francis Tetrahedron Letters, 1987 , vol. 28, # 23 p. 2579 - 2582]
[Zhang; Archelas; Meou; Furstoss Tetrahedron Asymmetry, 1991 , vol. 2, # 4 p. 247 - 250]