Chemistry Letters

Synthesis of. GAMMA.-ketopimelic acid derivatives by rhodium carbonyl-catalyzed hydrocarbonylation of acrylic acid derivatives.

P Hong, T Mise, H Yamazaki

Index: Hong, Pangbu; Mise, Takaya; Yamazaki, Hiroshi Chemistry Letters, 1982 , p. 361 - 364

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Citation Number: 7

Abstract

The rhodium carbonyl-catalyzed reactions of acrylic acid derivatives (1) with CO in iso- propanol gave selectively γ-ketopimelic acid derivatives (2) in good yields. In the reaction of ethyl acrylate (1b) in iso-propanol-d 8, deuterium scrambling in the methylene groups of the product (2b) was observed.

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