Facile Synthesis of Sterically Hindered and Electron??Deficient Secondary Amides from Isocyanates

G Schäfer, C Matthey, JW Bode

Index: Schaefer, Gabriel; Matthey, Coraline; Bode, Jeffrey W. Angewandte Chemie - International Edition, 2012 , vol. 51, # 36 p. 9173 - 9175

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Citation Number: 24

Abstract

Amide bond formation is widely regarded as the most used chemical reaction in drug discovery.[1] Despite the importance of amides, nearly all are formed by reactions operating under a single mechanistic approach: dehydrative condensation of amines and carboxylic acids by the action of a coupling agent.[2] This approach has proven to be highly suitable, albeit often wasteful and expensive, for the majority of amides.[3] An exception is the ...