Remarkable effects of donor esters on the α-chymotrypsin-catalyzed couplings of inherently poor amino acid substrates
T Miyazawa, K Tanaka, E Ensatsu, R Yanagihara…
Index: Miyazawa, Toshifumi; Tanaka, Kayoko; Ensatsu, Eiichi; Yanagihara, Ryoji; Yamada, Takashi Tetrahedron Letters, 1998 , vol. 39, # 9 p. 997 - 1000
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Citation Number: 17
Abstract
The extremely low efficiency during the α-chymotrypsin-catalyzed coupling of an inherently poor amino acid substrate, eg, alanine, using the methyl ester as an acyl donor was significantly improved using esters such as the 2, 2, 2-trifluoroethyl or carbamoylmethyl ester. The ameliorating effect of the latter ester was especially significant.
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