Polycyclic guanidine-containing compounds from the Mediterranean sponge Crambe crambe: the structure of 13, 14, 15-isocrambescidin 800 and the absolute …

EA Jares-Erijman, AL Ingrum, JR Carney…

Index: Jares-Erijman; Ingrum; Carney; Rinehart; Sakai Journal of Organic Chemistry, 1993 , vol. 58, # 18 p. 4805 - 4808

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Citation Number: 89

Abstract

The absolute stereochemistry of the pentacyclic guanidine moieties of crambescidin 816 (1) l and of 13, 14, 15-isocrambescidin 800 (4), a new member of this family, was determined, based on chiral GC analysis of a derivative of 2-hydroxybutanoic acid, an ozonolysis product of the crambescidins. Significantly less antiviral activity and cytotoxicity were observed for 4.