Palladium-catalyzed cross-coupling of benzylzinc reagents with methylthio N-heterocycles: A new coupling reaction with unusual selectivity
ME Angiolelli, AL Casalnuovo, TP Selby
Index: Angiolelli, Mary E.; Casalnuovo, Albert L.; Selby, Thomas P. Synlett, 2000 , # 6 p. 905 - 907
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Citation Number: 38
Abstract
Abstract: Benzylzinc reagents undergo palladium-catalyzed crosscoupling reactions with methylthio-substituted N-heterocycles in moderate to good yields. 2-(Methylthio) pyrimidines are particularly reactive substrates for this reaction. As a result, the regioselectivity of 2, 4-bis (methylthio) pyrimidines is opposite to that of their 2, 4-dichloropyrimidine analogues. This unusual cross-coupling reaction offers new flexibility in the regioselective synthesis of ...
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