Rapid Access to α??Alkoxy and α??Amino Acid Derivatives through Safe Continuous??Flow Generation of Diazoesters

HE Bartrum, DC Blakemore, CJ Moody…

Index: Bartrum, Hannah E.; Blakemore, David C.; Moody, Christopher J.; Hayes, Christopher J. Chemistry - A European Journal, 2011 , vol. 17, # 35 p. 9586 - 9589

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Citation Number: 35

Abstract

Despite the wide synthetic potential of diazo compounds (XÀH insertion, ylide formation, cyclopropanation, cycloaddition etc.),[1] concerns over the hazards associated with their preparation, isolation, and use have hindered their full exploitation in both academic and industrial laboratories. A few diazo compounds are commercially available (eg ethyl and butyl diazoacetate, TMS-diazomethane and diazodimedone),[2] but safe and convenient ...