Small multivalent architectures mimicking homotrimers of the TNF superfamily member CD40L: delineating the relationship between structure and effector function

…, W Sun, O Chaloin, J Hoebeke, S Fournel…

Index: Trouche, Nathalie; Wieckowski, Sebastien; Sun, Weimin; Chaloin, Olivier; Hoebeke, Johan; Fournel, Sylvie; Guichard, Gilles Journal of the American Chemical Society, 2007 , vol. 129, # 44 p. 13480 - 13492

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Citation Number: 32

Abstract

Synthetic multivalent ligands, owing to the presence of multiple copies of a recognition motif attached to a central scaffold, can mediate clustering of cell surface receptors and thereby function as effector molecules. This paper dissects the relationship between structure and effector function of synthetic multivalent ligands targeting CD40, a cell surface receptor of the tumor necrosis factor receptor (TNF-R) superfamily. Triggering CD40 signaling in vivo can ...