Journal of the Chemical Society (Resumed)

480. Degradative studies on peptides and proteins. Part IV. The formation of salts of 2-acylaminothiazol-5-ones by acid-catalysed degradation of N- …

DT Elmore, PA Toseland

Index: Elmore; Toseland Journal of the Chemical Society, 1957 , p. 2460,2462

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Citation Number: 2

Abstract

N-Acylthiocarbamoylpeptides and their esters, under suitable conditions of acid catalysis, afford salts of 2-acylaminothiazol-5-ones. Nucleophilic reagents such as water, alcohols, and primary amines open the heterocyclic ring to give N-acylthiocarbamoylamino-acid