Synthesis of isomeric thienobenzothiazines and their effect on dopamine metabolism in rat brain

…, H Rollema, D Dijkstra, BHC Westerink

Index: Grol, Cor J.; Rollema, Hans; Dijkstra, Durk; Westernik, Ben H. C. Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 322 - 324

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Citation Number: 5

Abstract

Cor J. Grol,* Hans Rollema, Durk Dijkstra, and Ben H. C. Westerink ... Department of Medicinal Chemistry, State University, Groningen, The Netherlands. Received July 30, 1979 ... The synthesis of the thieno[2,3-b]-, thieno[3,4-b]-, and thieno[3,2-b]benzothiazines with a hydroxyethylpiperazinylpropyl side chain and various 2 substituents is described. The influence of these neuroleptic compounds on dopamine metabolism in vivo is quantitated by determining the rise in homovanillic ...