Journal of medicinal chemistry

Adriamycin analogs. Rationale, synthesis, and preliminary antitumor evaluation of highly active DNA-nonbinding N-(trifluoroacetyl) adriamycin 14-O-hemiester …

M Israel, PG Potti, R Seshadri

Index: Israel, Mervyn; Potti, P. Gopalakrishnan; Seshadri, Ramakrishnan Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1223 - 1228

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Citation Number: 35

Abstract

N-(Trifluoroacety1) adriamycin 14-valerate (AD 32), a novel DNA nonbinding analogue of adriamycin with superior experimental antitumor activity, has undergone extensive clinical trial, with documentation of antitumor activity and low toxicity in human subjects. However, poor water solubility necessitates that the drug be administered to patients by continuous intravenous infusion at high dilution in a surfactant-containing formulation, with steroid ...