Nonsteroidal inhibitors of human type I steroid 5-. alpha.-reductase

…, DE Lawhorn, LA McQuaid, BL Neubauer…

Index: Jones; Audia; Lawhorn; McQuaid; Neubauer; Pike; Pennington; Stamm; Toomey; Hirsch Journal of Medicinal Chemistry, 1993 , vol. 36, # 3 p. 421 - 423

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Citation Number: 99

Abstract

Elevated dihydrotestosterone (DHT), arising from the reduction of testosterone through the action of steroid 5a-reductase, has been implicated in a number of conditions including benign prostatic hyperplasia (BPH), l acne? hirs~ tism,~ and androgenic alopecia (male- pattern baldne~ s).~ A number of compounds have been identified as inhibitors of 5a- reductase, including both steroidal inhibitors, MK-W6 (1, Proscar, finasteride) and SKF ...