Journal of the American Chemical Society

Total synthesis of linear polyprenoids. 3. Syntheses of ubiquinones via palladium-catalyzed oligomerization of monoterpene monomers

D Eren, E Keinan

Index: Eren, Doron; Keinan, Ehud Journal of the American Chemical Society, 1988 , vol. 110, # 13 p. 4356 - 4362

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Citation Number: 61

Abstract

Abstract: A general methodology for highly regie and stereoselective Pd (0)-catalyzed, stepwise allylic coupling of bifunctional monomers was developed, representing a practical approach for total synthesis of naturally occurring polyprenoids. As an example, the total synthesis of the cardiovascular agent ubiquinone 10 (coenzyme Qlo), as well as shorter ubiquinones, was carried out via selective coupling of monomers easily derived from ...