The Journal of organic chemistry

Room temperature cross-coupling of highly functionalized organozinc reagents with thiomethylated N-heterocycles by nickel catalysis

L Melzig, A Metzger, P Knochel

Index: Melzig, Laurin; Metzger, Albrecht; Knochel, Paul Journal of Organic Chemistry, 2010 , vol. 75, # 6 p. 2131 - 2133

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Citation Number: 47

Abstract

A variety of thiomethyl-substituted N-heterocycles such as pyridines, isoquinolines, pyrimidines, pyrazines, pyridazines, quinazolines, triazines, benzothiazoles, or benzoxazoles undergo smooth Ni-catalyzed cross-coupling reactions with functionalized aryl-, heteroaryl-, alkyl-, and benzylic zinc reagents using an inexpensive Ni (acac) 2/DPE- Phos catalytic system at 25° C.