Antiviral Chemotherapy. II. Structure-Activity Relationships in a Series of Isothiazolealdehyde and Ketone Thiosemicarbazones1a

MPL Caton, DH Jones, R Slack, S Squires…

Index: Caton,M.P.L. et al. Journal of Medicinal Chemistry, 1965 , vol. 8, p. 680 - 683

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Citation Number: 10

Abstract

\Vc have reported previouslyia 1 hat oral adniinistra- t ioii of 4-formylpyridine thioseiiiicarbazone affords iiiarlted protection to mice infeoted iritracerebrally with iieurovaccinia. It was further denioiistrated that nucalcar substitution abolished or reduced aril iviral art ivity and that, of several possible metabolites, oiily 3-iiiercapto-5- (4-pyridyl) -1,2,4 (H) -triazole had coiii- \)arable activity. The present coriimunicatioii IS coli- ccrned with another line of development, vix., the syii- thesis and ...