The synthesis of cyclic and acyclic long??chain arylpiperazine derivatives of salicylamide as serotonin receptor ligands

P Kowalski, J Jaśkowska, AJ Bojarski…

Index: Kowalski, Piotr; Jaskowska, Jolanta; Bojarski, Andrzej J.; Duszynska, Beata Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 1 p. 209 - 214

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Citation Number: 11

Abstract

Long-chain arylpiperazines with a general structure presented in Figure 1 are the largest class of 5-HT1A serotonin receptor ligands [1-4]. An Ar group attached to N1 of a piperazine moiety is usually a substituted phenyl or heteroaromatic (one or two rings) system. With regard to the alkyl chain, two to four methylene groups (n= 0–2) are optimal for 5-HT1A activity. The terminus usually contains an amide or an imide function, but neither is ...

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