The Reaction of 2-Bromopyridine N-Oxides with Active Methylene Compounds

R Adams, W Reifschneider

Index: Adams; Reifschneider Journal of the American Chemical Society, 1957 , vol. 79, p. 2236

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Citation Number: 4

Abstract

The electron-attracting power of the ring nitrogen accounts for the facile attack of halogen in the 2-and 4-halopyridines by nucleophilic reagents. In spite of this reactivity, the bromine atom in 2-bromopyridine fails to respond to treatment with diethyl sodiomalonate. The introduction of the malonic ester group in the 2-position of pyridine was achieved2 by using 5-nitro-2-chloropyridine in which the halogen is further activated by the electron- ...

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