Glyoxalase 1 and 2 enzyme inhibitory activity of 6-sulfamoylsaccharin and sulfocoumarin derivates

M Makrecka, R Zalubovskis, E Vavers…

Index: Makrecka, Marina; Zalubovskis, Raivis; Vavers, Edijs; Ivanova, Jekaterina; Grandane, Aiga; Dambrova, Maija Letters in Drug Design and Discovery, 2013 , vol. 10, # 5 p. 410 - 414

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Citation Number: 4

Abstract

The glyoxalase enzymes represent a cellular defence system against the accumulation of cytotoxic α-oxoaldehydes leading to apoptosis. The potential of glyoxalase inhibitors to act as novel anti-cancer agents for drugresistant tumours that over-express glyoxalase is currently under investigation. In the present study, a series of 6-sulfamoylsaccharin and 1, 2- benzoxathiine 2, 2-dioxide (sulfocoumarin-coumarin bioisostere) derivates, as well as, ...