Tetrahedron

Nickel-catalyzed cycloisomerization of enynes: catalyst generation via C–H activation of carbene ligands

TN Tekavec, J Louie

Index: Tekavec, Thomas N.; Louie, Janis Tetrahedron, 2008 , vol. 64, # 29 p. 6870 - 6875

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Citation Number: 22

Abstract

The combination of Ni (0) and an N-heterocyclic carbene acts as a precatalyst for the cycloisomerization of enynes to afford 1, 3-dienes. During the course of the reaction, a nickel hydride is formed from oxidative addition of the ortho C–H on the carbene ligand. Deuterium labeling studies are presented.