Aza??Analogs of 8??Styrylxanthines as A2A??Adenosine Receptor Antagonists

…, U Geis, W Frobenius, P Talik, M Pawlowski

Index: Mueller, Christa E.; Sauer, Roland; Geis, Uli; Frobenius, Wolfram; Talik, Przemyslaw; Pawlowski, Muciej Archiv der Pharmazie, 1997 , vol. 330, # 6 p. 181 - 189

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Citation Number: 21

Abstract

Abstract In the present study we synthesized aza-analogs of 8-styrylxanthines, in which the ethenyl bridge is replaced by an imine, amide, or azo function, in order to investigate structure-activity relationships of the 8-substituent of A 2A-selective xanthine derivatives. Thus, various 8-substituents were combined with theophylline or caffeine, respectively, and affinities of the novel compounds for adenosine A 1-and A 2A-receptors were determined ...