Tetrahedron Letters

Efficient and scalable synthesis of ketones via nucleophilic Grignard addition to nitriles using continuous flow chemistry

C Mateos, JA Rincón, J Villanueva

Index: Mateos, Carlos; Rincon, Juan A.; Villanueva, Jose Tetrahedron Letters, 2013 , vol. 54, # 18 p. 2226 - 2230

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Citation Number: 9

Abstract

In the present Letter we report the development of efficient continuous flow chemistry conditions for the scalable preparation of ketones. This transformation is achieved via nucleophilic addition of Grignard reagents to the corresponding nitriles and imine hydrolysis by means of in-series plug flow reactors.