Tetrahedron

Fischer synthesis of isomeric thienopyrrole LHRH antagonists

…, CS Harris, C Lambert-van der Brempt, M Lamorlette…

Index: Andrews, David M.; Arnould, Jean-Claude; Boutron, Pascal; Delouvrie, Benedicte; Delvare, Christian; Foote, Kevin M.; Hamon, Annie; Harris, Craig S.; Lambert-van der Brempt, Christine; Lamorlette, Maryannick; Matusiak, Zbegniew M. Tetrahedron, 2009 , vol. 65, # 29-30 p. 5805 - 5816

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Citation Number: 8

Abstract

As part of a structure–activity exploration into LHRH antagonists, structures containing the thieno [2, 3-b] pyrrole core were identified as potent antagonists. This letter describes the employment of the Fischer synthesis to access this thienopyrrole and isomeric final compounds.